Rare instances of liver toxicity/damage have been reported with this medication and it is therefore recommended to monitor your liver enzymes (ALT/AST) once a year.
Bicalutamide
| Seller | Product | Price | Single $/50mg | Bulk $/50mg | Stock | Notes |
|---|---|---|---|---|---|---|
| Pharmacy-House | Bicalutamide 150mg x 30 | $85.48 | $0.95 | $0.93 | Yes | |
| TeaHRT | Bicalutamide 50mg x 100 | $75.00 | $0.75 | $0.80 | 69 days ago | |
| Bulgarian Online Pharmacy | Bicalutamide Accord 50mg x 30 | £25.00 | $0.83 | $0.83 | Unknown | |
| Pilloid | Bicalutamide Cannon 50mg x 30 | $38.75 | $1.29 | $1.29 | Unknown | |
| Pilloid | Bicalutamide Teva 50mg x 28 | $43.94 | $1.57 | $1.57 | Unknown | |
| Medicina Mexico | Bicotexida 50mg x 28 | $106.00 | $3.79 | $3.79 | Unknown | |
| Medicina Mexico | Bilumiv 50mg x 28 | $150.00 | $5.36 | $5.36 | Unknown | |
| Inhouse Pharmacy | Binarex 50mg x 28 | $66.00 | $2.36 | $2.36 | Unknown | |
| United Pharmacies (NL) | Calutide 50mg x 10 | €20.85 | $2.08 | $1.94 | No | |
| United Pharmacies (US) | Calutide 50mg x 10 | $23.02 | $2.30 | $2.14 | Yes | |
| United Pharmacies (UK) | Calutide 50mg x 10 | £18.93 | $1.89 | $1.76 | Yes | |
| 4NRX Pharmacy | Calutide 50mg x 10 | £18.56 | £1.86 | £1.86 | No | |
| Inhouse Pharmacy | Calutide 50mg x 30 | $82.50 | $2.75 | $2.75 | Unknown | |
| ReliableRx Pharmacy | Calutide 50mg x 30 | $65.41 | $2.18 | $2.18 | Yes | |
| AllDayChemist | Calutide 50mg x 30 | $59.63 | $1.99 | $1.99 | Yes | |
| United Pharmacies (UK) | Casodex 150mg x 28 | £81.05 | $0.96 | $0.96 | No | |
| RxAisle | Casodex 150mg x 28 | $59.00 | $0.70 | $0.59 | Unknown | |
| 4NRX Pharmacy | Casodex 150mg x 28 | £79.43 | £0.95 | £0.95 | No | |
| United Pharmacies (US) | Casodex 150mg x 28 | $99.90 | $1.19 | $1.19 | No | |
| Dragon Ordnance | Casodex 150mg x 28 | $85.00 | $1.01 | $1.01 | Yes | |
| Favskinhouse | Casodex 50mg x 28 | $58.00 | $2.07 | $2.07 | Unknown | |
| Dragon Ordnance | Casodex 50mg x 28 | $25.00 | $0.89 | $0.89 | Yes | |
| Silhouette Beauty | Casodex 50mg x 28 | €38.50 | $1.38 | $1.38 | Unknown | |
| RxAisle | Casodex 50mg x 28 | $59.00 | $2.11 | $1.77 | Unknown | |
| DashPCT | Castramid 50mg x 10 | $11.00 | $1.10 | $1.10 | Yes | |
| United Pharmacies (UK) | Procalut 50mg x 28 | £24.98 | $0.89 | $0.83 | No | |
| United Pharmacies (US) | Procalut 50mg x 28 | $30.38 | $1.08 | $1.01 | No | |
| 4NRX Pharmacy | Procalut 50mg x 28 | £24.48 | £0.87 | £0.87 | No | |
| Otokonoko Pharmaceuticals | Bicalutamide 50mg x 50 | $50.00 | $1.00 | $1.00 | Yes | This seller is currently suffering delays |
Info
Bicalutamide functions as an anti-androgen by competing with testosterone and blocking its activity at the androgen receptor. While it is commonly prescribed as an anti-androgen, its usage is less common within the United States.
Dosing
| Dose | Amount Per Day | Amount Every Other Day |
|---|---|---|
| Minimum | 25mg daily | 50mg bi-daily |
| Typical Starting | 50mg daily | 100mg bi-daily |
| Maximum Dose | 50mg daily | 100mg bi-daily |
| Maximum Safe | 100mg daily | 200mg bi-daily |
- There is no reason to go above the maximum dose when taken in conjunction with estrogen.
- Some people use bicalutamide mono-therapy, information on the topic can be found here.
Monitoring
Adjusting bicalutamide dose from the starting dose is typically not needed, however there are some blood tests you should monitor.
Liver AST/ALT
Liver tests should be done at least six months after starting and once a year after, and it can be afforded three months in, six months in, and every six months after.
AST Normal Ranges: 8-33 U/L (Cleavland Clinic).
ALT Normal Range: 7-56 U/L (Cleavland Clnic).
Ranges on liver tests can vary significantly depending on demographics, however if out of range discontinue the medication and consult with a doctor (in these situations switching to injection monotherapy might be best).
Testosterone
Bicalutamide does not decrease blood levels of testosterone and may actually cause them to increase as the body tries to compensate for the reduction of androgen receptor activity. This is not a cause for concern. (Randolph John, 2018).
Safety and Effects
Bicalutamide and Liver Toxicity
These symptoms can be a major sign that you are experiencing a acute problem with your liver, if you are experiencing these please see a doctor:
- Yellowing of the skin and eye whites (jaundice)
- Abdominal pain in the upper right portion of the abdomen
- Dark or tea-colored urine.
This list is not conclusive however these signs are serious indicators of liver issues (others are detailed in the source) Mayo Clinic.
The risk for liver toxicity in prostate cancer patients is small (one in four thousand); this risk of liver toxicity in transgender patients taking a much smaller dose as an anti-androgen is undoubtedly significantly lower, but this risk has not been studied. If possible, doing a liver panel after long-term use of bicalutamide is a good idea. (Aly 2020).